Muraoka Group

Tokyo University of Agriculture and Technology


Protein Aggregation Suppression and Folding Promotion by Synthetic Molecules

Takahiro Muraoka

Soft Matter for Biomedical Applications (Soft Matter Series), Royal Society of Chemistry, 2021.


Thermo-Driven Self-Assembly of a PEG-Containing Amphiphile in a Bilayer Membrane

Rui Li, Takahiro Muraoka and Kazushi Kinbara

RSC Adv. 2020, 10, 25758–25762 (10.1039/D0RA03920A).


A Synthetic Ion Channel with Anisotropic Ligand Response

Takahiro Muraoka, Daiki Noguchi, Rinshi S. Kasai, Kohei Sato, Ryo Sasaki, Kazuhito V. Tabata, Toru Ekimoto, Mitsunori Ikeguchi, Kiyoto Kamagata, Norihisa Hoshino, Hiroyuki Noji, Tomoyuki Akutagawa, Kazuaki Ichimura and Kazushi Kinbara

Nature Commun. 2020, 11, 2924 (10.1038/s41467-020-16770-z) ("Behind the Paper" blog in Nature Research Bioengineering Community).


Reversible Formation of Multiple Stimuli-responsive Polymeric Materials through Processing Control of Trifunctional Amphiphilic Molecule

Takahiro Muraoka, Hidetaka Honda, Kota Nabeya and Kazushi Kinbara

Chem. Commun. 2020, 56, 7881–7884 (10.1039/D0CC02716B).



Sequence-dependent Bioactivity and Self-assembling Properties of RGD-containing Amphiphilic Peptides as Extracellular Scaffolds

Atsuya Ishida, Mio Oshikawa, Itsuki Ajioka and Takahiro Muraoka

ACS Appl. Bio Mater. 2020, 3, 3605–3611 (10.1021/acsabm.0c00240).


New Modified Deoxythymine with Dibranched Tetraethylene Glycol Stabilizes G-quadruplex Structures

Hisae Tateishi-Karimata, Tatsuya Ohyama, Takahiro Muraoka, Shigenori Tanaka, Kazushi Kinbara and Naoki Sugimoto

Molecules 2020, 25, 705 (10.3390/molecules25030705).


Biofunctional Molecules Inspired by Protein Mimicry and Manipulation

Takahiro Muraoka

Bull. Chem. Soc. Jpn. 2020, 93, 138–153  (10.1246/bcsj.20190315).


Abiotic Factors Promote Cell Penetrating Peptide Permeability in Enterobacteriaceae Models

Daichi Toyohara, Yasuhito Yokoi, Go Inoue, Takahiro Muraoka, and Tetsushi Mori

Front. Microbiol. 2019, 10, 2534 (10.3389/fmicb.2019.02534).


Glycine Substitution Effects on the Supramolecular Morphology and Rigidity of Cell-Adhesive Amphiphilic Peptides

Atsuya Ishida, Go Watanabe, Mio Oshikawa, Itsuki Ajioka, and Takahiro Muraoka

Chem. Eur. J. 2019, 25, 13523–13530 (10.1002/chem.201902083).


Formation of Giant and Small Cyclic Complexes from a Flexible Tripeptide Ligand Controlled by Metal Coordination and Hydrogen Bonds

Ryosuke Miyake, Akira Ando, Manami Ueno, and Takahiro Muraoka

J. Am. Chem. Soc. 2019, 141, 8675–8679 (10.1021/jacs.9b01541).


Coupling Effects of Thiol and Urea-Type Groups for Promotion of Oxidative Protein Folding

Shunsuke Okada, Motonori Matsusaki, Kenta Arai, Yuji Hidaka, Kenji Inaba, Masaki Okumura, and Takahiro Muraoka

Chem. Commun. 2019, 55, 759–762 (Highlighted in Inside Back Cover, Japanese Science Newspaper (2019/Jan/1), Japanese Science Magazine10.1039/C8CC08657E).


Heat-Triggered Crystallization of Liquid Crystalline Macrocycles Allowing for Conductance Switching through Hysteretic Thermal Phase Transitions

Takahiro Muraoka, Tatsuya Shima, Takashi Kajitani, Norihisa Hoshino, Estelle Morvan, Axelle Grélard, Erick J. Dufourc, Takanori Fukushima, Tomoyuki Akutagawa, Kota Nabeya, and Kazushi Kinbara

Chem. Asian J. 2019, 14, 141–148 (Highlighted in Front Cover, 10.1002/asia.201801372).


Design of C2-Symmetric Alkaloidal Chiral Amphiphiles and Configurational Effects on Self-Assembly
Nana Tsuchiya, Yunosuke Ryu, Takahiro Muraoka, and Hiroki Oguri

Org. Biomol. Chem. 2018, 16, 9305–9313 (Highlighted in Front Cover, 10.1039/C8OB02287A).


Localization of Transmembrane Multiblock Amphiphilic Molecules in Phase-Separated Vesicles

Kazushi Kinbara, Kaori Umetsu, Hiroki Sonobe, Takahiro Muraoka, Naofumi Shimokawa and Masahiro Takagi

Faraday Discuss. 2018, 209, 315–328 (10.1039/C8FD00022K).


Thermal and Optical Properties of Multiblock Macrocycles with Hysteretic Polymorphic Transition

Kota Nabeya, Takahiro Muraoka, Norihisa Hoshino, Miho Aizawa, Takashi Kajitani, Tomoyuki Akutagawa, Atsushi Shishido, Takanori Fukushima, and Kazushi Kinbara

Mater. Chem. Front. 2018, 2, 969–974 (10.1039/C7QM00621G).


Enzymatically Cleavable Traceless Biotin Tag for Protein PEGylation and Purification

Adam Marcin Wawro, Yusuke Aoki, Takahiro Muraoka, Kouhei Tsumoto, and Kazushi Kinbara

Chem. Commun. 2018, 54, 1913–1916 (10.1039/C7CC05814D).


Multifarious Polymorphism of Multi-Block Amphiphilic Macrocycle Bearing Thermally Responsive Polyether Segment

Takahiro Muraoka, Tatsuya Shima, and Kazushi Kinbara

ACS Omega 2018, 3, 414–418 (10.1021/acsomega.7b01737).


Bio-inspired Multiblock Molecules for Membrane Functionalization

Takahiro Muraoka

Biol. Pharm. Bull. 2018, 41, 294–302 (10.1248/bpb.b17-00652, Invited Review, Current Topics).


Mechano-Sensitive Synthetic Ion Channels

Takahiro Muraoka, Kaori Umetsu, Kazuhito V. Tabata, Tsutomu Hamada, Hiroyuki Noji, Takashi Yamashita, and Kazushi Kinbara

J. Am. Chem. Soc. 2017, 139, 18016–18023 (10.1021/jacs.7b09515, Highlighted in JACS Spotlights).


Thermally-Induced Lateral Assembly of PEG-Containing Amphiphile Triggering Vesicle Budding

Rui Li, Takahiro Muraoka, and Kazushi Kinbara

Chem. Commun. 2017, 53, 11662–11665 (10.1039/C7CC06489F).


Newly Characterized Interaction Stabilizes DNA Structure: Oligoethylene Glycols Stabilize G-Quadruplexes CH–π Interactions

Hisae Tateishi-Karimata, Tatsuya Ohyama, Takahiro Muraoka, Peter Podbevsek, Adam M. Wawro, Shigenori Tanaka, Shu-ichi Nakano, Kazushi Kinbara, Janez Plavec, and Naoki Sugimoto

Nucleic Acids Res. 2017, 45, 7021–7030 (Highlighted in Front Cover, 10.1093/nar/gkx299).



Multigram Chromatography-Free Synthesis of Octa(ethylene glycol) p-Toluenesulfonate

Adam M. Wawro, Takahiro Muraoka, Maho Kato, and Kazushi Kinbara

Org. Chem. Front. 2016, 3, 1524–1534 (10.1039/C6QO00398B).



G-Quadruplexes with Tetraethylene Glycol-Modified Deoxythymidines Are Resistant to Nucleases and Inhibit HIV-1 Reverse Transcriptase

Hisae Tateishi-Karimata, Takahiro Muraoka, Kazushi Kinbara, and Naoki Sugimoto

ChemBioChem 2016, 17, 1399–1402 (selected as the Cover, 10.1002/cbic.201600162).



Contrasting Topological Effect of PEG-Containing Amphiphiles to Natural Lipids on Stability of Vesicles

Rui Li, Takahiro Muraoka, and Kazushi Kinbara

Langmuir 2016, 32, 4546–4553 (10.1021/acs.langmuir.6b00713).



Chromatography-Free Synthesis of Monodisperse Oligo(ethylene glycol) Mono-p-Toluenesulfonates and Quantitative Analysis of Oligomer Purity

Adam M. Wawro, Takahiro Muraoka, and Kazushi Kinbara

Polym. Chem. 2016, 7, 2389–2394.



Synthesis and Thermal Responses of Polygonal Poly(ethylene glycol) Analogues

Shunichi Kawasaki, Takahiro Muraoka, Tsutomu Hamada, Kazuki Shigyou, Fumi Nagatsugi and Kazushi Kinbara

Chem. Asian J. 2016, 11, 1028–1035 (selected as a Very Important Paper (VIP) & Top Cover, Highlighted in ChemitryViews, 10.1002/asia.201501381).



Bioinspired Multi-Block Molecules

Takahiro Muraoka and Kazushi Kinbara

Chem. Commun. 2016, 52, 2667–2678 (Feature Article, Selected as the Inside Back Cover, 10.1039/C5CC08052E).



Development of Stimuli-Responsive Multi-Block Amphiphiles

Takahiro Muraoka, Shunichi Kawasaki, and Kazushi Kinbara

J. Photopolym. Sci. Tec. 2015, 28, 579–582.



Protein Stabilization by an Amphiphilic Short Monodisperse Oligo(ethylene glycol)

Nabanita Sadhukhan, Takahiro Muraoka, Mihoko Ui, Satoru Nagatoishi, Kouhei Tsumoto, and Kazushi Kinbara

Chem. Commun. 2015, 51, 8457–8460.


Reversible Ion Transportation Switch by a Ligand-Gated Synthetic Supramolecular Ion Channel

Takahiro Muraoka, Takahiro Endo, Kazuhito V. Tabata, Hiroyuki Noji, Satoru Nagatoishi, Kouhei Tsumoto, Rui Li and Kazushi Kinbara

J. Am. Chem. Soc. 2014, 136, 15584–15595.



Grafting Synthetic Transmembrane Units to the Engineered Low-Toxicity alpha-Hemolysin to Restore Its Hemolytic Activity

Mihoko Ui, Kousuke Harima, Toshiaki Takei, Kouhei Tsumoto, Kazuhito V. Tabata, Hiroyuki Noji, Sumire Endo, Kimio Akiyama, Takahiro Muraoka, and Kazushi Kinbara

Mol. BioSyst. 2014, 10, 3199–3206.



Light-Triggered Vesicle Formation: Important Factors for Generation of Vesicles and Possible Applications

Tatsuya Shima, Takahiro Muraoka, Kazuhito V. Tabata, Hiroyuki Noji and Kazushi Kinbara

Pure Appl. Chem. 2014, 86, 1259–1267.



Single-Cell E. coli Response to an Instantaneously Applied Chemotactic Signal

Takashi Sagawa, Yu Kikuchi, Yuichi Inoue, Hiroto Takahashi, Takahiro Muraoka, Kazushi Kinbara, Akihiko Ishijima and Hajime Fukuoka

Biophys. J. 2014, 107, 730–739.



Thermodriven Micrometer-Scale Aqueous-Phase Separation of Amphiphilic Oligoethylene Glycol Analogues

Shunichi Kawasaki, Takahiro Muraoka, Haruki Obara, Takerou Ishii, Tsutomu Hamada and Kazushi Kinbara

Chem. Asian J. 2014, 9, 2778–2788 (Selected as the Back Cover).



Development of Self-Assembling Alternating Amphiphilic Compounds

Takahiro Muraoka, Nabanita Sadhukhan, Rui Li and Kazushi Kinbara

J. Photopolym. Sci. Tec. 2014, 27, 557–560.



Micrometer-Size Vesicle Formation Triggered by UV Light

Tatsuya Shima, Takahiro Muraoka, Tsutomu Hamada, Masamune Morita, Masahiro Takagi, Hajime Fukuoka, Yuichi Inoue, Takashi Sagawa, Akihiko Ishijima, Yuki Omata, Takashi Yamashita and Kazushi Kinbara

Langmuir 2014, 30, 7289–7295.



Thermally Driven Polymorphic Transition Prompting a Naked-Eye-Detectable Bending and Straightening Motion of Single Crystals

Tatsuya Shima, Takahiro Muraoka, Norihisa Hoshino, Tomoyuki Akutagawa, Yuka Kobayashi and Kazushi Kinbara

Angew. Chem. Int. Ed. 2014, 53, 7173–7178.



Thermoresponsive Self-assembly and Conformational Changes of Amphiphilic Monodisperse Short Poly(ethylene glycol)s in Water

Nabanita Sadhukhan, Takahiro Muraoka, Daisuke Abe, Yuji Sasanuma, Dwiky Rendra Graha Subekti and Kazushi Kinbara

Chem. Lett. 2014, 43, 1055–1057.



Transetherification on Polyols by Intra- and Intermolecular Nucleophilic Substitutions

Takahiro Muraoka, Kota Adachi, Rainy Chowdhury and Kazushi Kinbara

PLoS ONE 2014, 9, e91912.



Thermal-Aggregation Suppression of Proteins by a Structured PEG Analogue: Importance of Denaturation Temperature for Effective Aggregation Suppression

Takahiro Muraoka, Nabanita Sadhukhan, Mihoko Ui, Shunichi Kawasaki, Enrikko Hazemi, Kota Adachi, and Kazushi Kinbara

Biochem. Eng. J. 2014, 86C, 41–48.



Development and Functionalization of Structural Mimics of Multipass Transmembrane Proteins

Takahiro Muraoka and Kazushi Kinbara

J. Syn. Org. Chem. Jpn. 2013, 71, 1045–1050.



A Structured Monodisperse PEG for the Effective Suppression of Protein Aggregation

Takahiro Muraoka, Kota Adachi, Mihoko Ui, Shunichi Kawasaki, Nabanita Sadhukhan, Haruki Obara, Hidehito Tochio, Masahiro Shirakawa, and Kazushi Kinbara

Angew. Chem. Int. Ed. 2013, 52, 2430–2434 [Selected as a “Very Important Paper (VIP)” & a “Back Cover”, Highlighted in Wiley-JAPAN Science Cafe].



Ion Permeation by a Folded Multiblock Amphiphilic Oligomer Achieved by Hierarchical Construction of Self-Assembled Nanopores

Takahiro Muraoka, Tatsuya Shima, Tsutomu Hamada, Masamune Morita, Masahiro Takagi, Kazuhito V. Tabata, Hiroyuki Noji, and Kazushi Kinbara

J. Am. Chem. Soc. 2012, 134, 19788–19794. (DOI: 10.1021/ja308342g).



Development of Photoresponsive Supramolecular Machines Inspired by Biological Molecular Systems

Takahiro Muraoka, and Kazushi Kinbara

J. Photoch. Photobio. C 2012, 13, 136–147.



Mimicking Multipass Transmembrane Proteins: Synthesis, Assembly and Folding of Alternating Amphiphilic Multiblock Molecules in Liposomal Membranes

Takahiro Muraoka, Tatsuya Shima, Tsutomu Hamada, Masamune Morita, Masahiro Takagi, and Kazushi Kinbara

Chem. Commun. 2011, 47, 194–196. [Selected as a Hot Article, Emerging Investigators Issue]



Light-Triggered Bioactivity in Three Dimensions

Takahiro Muraoka, Chung-Yan Koh, Honggang Cui, and Samuel I. Stupp

Angew. Chem. Int. Ed. 2009, 48, 5946–5949 [Selected as a “Hot Paper”].



Self-Assembly of Giant Peptide Nanobelts

Honggang Cui, Takahiro Muraoka, Andrew G. Cheetham, and Samuel I. Stupp

Nano Lett. 2009, 9, 945–951.



Chiral Ferrocenes as Novel Rotary Modules for Molecular Machines

Kazushi Kinbara, Takahiro Muraoka, and Takuzo Aida

Org. Biomol. Chem. 2008, 1871–1876 [Selected as “Emerging Area” and “Front Cover”; The Top 10 Downloaded Articles in May 2008].



Quadruple Helix Formation of a Photoresponsive Peptide Amphiphile and Its Light-Triggered Dissociation into Single Fibers

Takahiro Muraoka, Honggang Cui, and Samuel I. Stupp

J. Am. Chem. Soc. 2008, 130, 2946–2947.



Reversible Operation of Chiral Molecular Scissors by Redox and UV Light

Takahiro Muraoka, Kazushi Kinbara, and Takuzo Aida

Chem. Commun. 2007, 1441–1443.



Crystallographic and Chiroptical Studies on Tetraarylferrocenes for Use as Chiral Rotary Modules for Molecular Machines

Takahiro Muraoka, Kazushi Kinbara, Atsushi Wakamiya, Shigehiro Yamaguchi, and Takuzo Aida

Chem. Eur. J. 2007, 13, 1724–1730.



A Self-Locking Molecule Operative with a Photoresponsive Key

Takahiro Muraoka, Kazushi Kinbara, and Takuzo Aida

J. Am. Chem. Soc. 2006, 128, 11600–11605.



Mechanical Twisting of a Guest by a Photoresponsive Host

Takahiro Muraoka, Kazushi Kinbara, and Takuzo Aida

Nature 2006, 440, 512–515 [Highlighted in Angewandte Chemie, C&EN,, Newscientist and].forHP



Functionalization of Light-Driven Chiral Molecular Scissors

Takahiro Muraoka, Kazushi Kinbara, Yuka Kobayashi, and Takuzo Aida

J. Porphyr. Phthalocya. 2004, 8, 774.



Light-Driven Open-Close Motion of Chiral Molecular Scissors

Takahiro Muraoka, Kazushi Kinbara, Yuka Kobayashi, and Takuzo Aida

J. Am. Chem. Soc. 2003, 125, 5612–5613 [Highlighted in Newscientist].