発表論文

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Activator of KAT3 Histone Acetyltransferase Family Ameliorates a Neurodevelopmental Disorder Phenotype in the Syntaxin 1A Ablated Mouse Model

Takahiro Nakayama, Akash K. Singh, Toshiyuki Fukutomi, Noriyuki Uchida, Yasuo Terao, Hiroki Hamada, Takahiro Muraoka, Eswaramoorthy Muthusamy, Tapas K. Kundu, Kimio Akagawa

Cell Rep. 2024, 43, 114101 (10.1016/j.celrep.2024.114101, Open Access).

(74)

Enzymatic and Synthetic Regulation of Polypeptide Folding

Takahiro Muraoka, Masaki Okumura, Tomohide Saio

Chem. Sci. 2024, 15, 2282–2299 (10.1039/D3SC05781J, プレスリリース, Open Access).

(73)

Rapid Synthesis of Chiral Figure-Eight Macrocycles Using a Preorganized Natural Product-Based Scaffold

Tasuku Honda, Daiji Ogata, Makoto Tsurui, Satoshi Yoshida, Sota Sato, Takahiro Muraoka, Yuichi Kitagawa, Yasuchika Hasegawa, Junpei Yuasa, Hiroki Oguri

Angew. Chem. Int. Ed. 2024, 63, e202318548 (10.1002/anie.202318548, プレスリリース, Open Access).

(72)

Self-assembling Materials Functionalizing Bio-interfaces of Phospholipid Membranes and Extracellular Matrices

Noriyuki Uchida and Takahiro Muraoka*

Chem. Commun. 2023, 59, 9687–9697 (10.1039/D3CC01875J, highlighted in Pioneering Investigators Collections 2023).

(71)

Semi-Enzymatic Acceleration of Oxidative Protein Folding by N-Methylated Heteroaromatic Thiols

Shunsuke Okada,† Yosuke Matsumoto,† Rikana Takahashi, Kenta Arai, Shingo Kanemura, Masaki Okumura* and Takahiro Muraoka*

Chem. Sci. 2023, 14, 7630–7636 (10.1039/D3SC01540H, Open Access, † equal contribution, プレスリリース).

(70)

Supramolecular Chemistry of Multiblock Amphiphiles

Takahiro Muraoka

Supramolecular Nanotechnology: Advanced Design of Self-Assembled Functional Materials

(Editors: Omar Azzaroni, Martin Conda-Sheridan), Wiley-VCH, 2023.

(69)

Endocytosis-Like Vesicle Fission Mediated by a Membrane-Expanding Molecular Machine Enables Virus Encapsulation for In Vivo Delivery

Noriyuki Uchida, Yunosuke Ryu, Yuichiro Takagi, Ken Yoshizawa, Kotono Suzuki, Yasutaka Anraku, Itsuki Ajioka, Naofumi Shimokawa, Masahiro Takagi, Norihisa Hoshino, Tomoyuki Akutagawa, Teruhiko Matsubara, Toshinori Sato, Yuji Higuchi, Hiroaki Ito, Masamune Morita and Takahiro Muraoka
J. Am. Chem. Soc. 2023, 145, 6210–6220 (10.1021/jacs.2c12348, Open Access, プレスリリース).

(68)

ROS-Triggered Gel–Sol Transition and Kinetics-Controlled Cargo Release by Methionine-Containing Peptides

Yoshika Hara, Atsuya Yaguchi, Hirotsugu Hiramatsu and Takahiro Muraoka

ChemBioChem 2023, 24, e202200798 (10.1002/cbic.202200798, selected as a Very Important Paper (VIP), highlighted in ChemBioTalents 2022).

(67)

Oxidative Protein Folding Promotion by Imidazoyl-Conjugated Thiol

Shunsuke Okada,† Yosuke Matsumoto,† Masaki Okumura and Takahiro Muraoka

Chem. Lett. 2023, 52, 202–205 (10.1246/cl.220537, † equal contribution).

(66)

Coacervate Formation of Elastin-like Polypeptides in Explicit Aqueous Solution Using Coarse-Grained Molecular Dynamics Simulations

Takuya Mabuchi, Junko Kijima, Yukino Yamashita, Erika Miura and Takahiro Muraoka

Macromolecules 2023, 56, 794–805 (10.1021/acs.macromol.2c02195).

(65)

Amphiphilic Peptide-tagged N-Cadherin Forms Radial Glial-like Fibers that Enhance Neuronal Migration in Injured Brain and Promote Sensorimotor Recovery

Yuya Ohno, Chikako Nakajima, Itsuki Ajioka, Takahiro Muraoka, Atsuya Yaguchi, Teppei Fujioka, Saori Akimoto, Misaki Matsuo, Ahmed Lotfy, Sayuri Nakamura, Vicente Herranz-Pérez, José Manuel García-Verdugo, Noriyuki Matsukawa, Naoko Kaneko and Kazunobu Sawamoto

Biomaterials 2023, 294, 122003 (10.1016/j.biomaterials.2023.122003).

(64)

Cysteine-Based Protein Folding Modulators for Trapping Intermediates and Misfolded Forms

Hayato Nishino,† Mai Kitamura,† Shunsuke Okada, Ryosuke Miyake, Masaki Okumura and Takahiro Muraoka

RSC Adv. 2022, 12, 26658–26664 (10.1039/D2RA04044A, Open Access, † equal contribution).

(63)

Biophysical Elucidation of Neural Network and Chemical Regeneration of Neural Tissue

Takahiro Muraoka,* Tomohide Saio and Masaki Okumura

Biophys. Physicobiol. 2022, 19, e190024 (10.2142/biophysico.bppb-v19.0024, Open Access).

(62)

Self-Assembling Molecular Medicine for the Subacute Phase of Ischemic Stroke

Takahiro Muraoka* and Itsuki Ajioka*

Neurochem. Res. 2022, 47, 2488–2498 (10.1007/s11064-022-03638-5, Open Access).

(61)

Stabilization of Bicelles Using Metal-Binding Peptide for Extended Blood Circulation

Yuichiro Takagi, Noriyuki Uchida, Yasutaka Anraku and Takahiro Muraoka

Chem. Commun. 2022, 58, 5164–5167 (10.1039/D2CC01058E).

(60)

Efficient Protein Incorporation and Release by a Jigsaw-Shaped Self-Assembling Peptide Hydrogel for Injured Brain Regeneration

Atsuya Yaguchi, Mio Oshikawa, Go Watanabe, Hirotsugu Hiramatsu, Noriyuki Uchida, Chikako Hara, Naoko Kaneko, Kazunobu Sawamoto, Takahiro Muraoka* and Itsuki Ajioka* (co-corresponding authors)

Nature Commun. 2021, 12, 6623 (10.1038/s41467-021-26896-3).

(59)

Supramolecular Transmembrane Ion Channels Formed by Multiblock Amphiphiles

Kohei Sato, Takahiro Muraoka and Kazushi Kinbara

Acc. Chem. Res. 2021, 54, 3700–3709 (10.1021/acs.accounts.1c00397).

(58)

Amphiphilic Peptides with Flexible Chains for Tuning Supramolecular Morphologies, Macroscopic Properties and Biological Functions

Takahiro Muraoka

J. Synth. Org. Chem. Jpn. 2021, 79, 1033–1040 (10.5059/yukigoseikyokaishi.79.1033).

(57)

Self-assembly of Amphiphilic Peptide in Phospholipid Membrane

Anju Kawakita, Noriyuki Uchida, Yunosuke Ryu and Takahiro Muraoka

J. Photopolym. Sci. Tec. 2021, 34, 155–159.

(56)

Hydrogel-stiffening and Non-cell Adhesive Properties of Amphiphilic Peptides with Central Alkylene Chains

Atsuya Yaguchi, Hirotsugu Hiramatsu, Atsuya Ishida, Mio Oshikawa, Itsuki Ajioka and Takahiro Muraoka

Chem. Eur. J. 2021, 27, 9295–9301 (Hot Paper, Front Cover, 10.1002/chem.202100739).

(55)

Critical Side Chain Effects of Cell-Penetrating Peptides for Transporting Oligo Peptide Nucleic Acids in Bacteria

Go Inoue, Daichi Toyohara, Tetsushi Mori and Takahiro Muraoka

ACS Appl. Bio Mater. 2021, 4, 3462–3468 (10.1021/acsabm.1c00023).

(54)

Protein Aggregation Suppression and Folding Promotion by Synthetic Molecules

Takahiro Muraoka

Soft Matter for Biomedical Applications (Soft Matter Series), Royal Society of Chemistry, 2021 (10.1039/9781839161124).

(53)

Thermo-Driven Self-Assembly of a PEG-Containing Amphiphile in a Bilayer Membrane

Rui Li, Takahiro Muraoka and Kazushi Kinbara

RSC Adv. 2020, 10, 25758–25762 (10.1039/D0RA03920A).

(52)

A Synthetic Ion Channel with Anisotropic Ligand Response

Takahiro Muraoka, Daiki Noguchi, Rinshi S. Kasai, Kohei Sato, Ryo Sasaki, Kazuhito V. Tabata, Toru Ekimoto, Mitsunori Ikeguchi, Kiyoto Kamagata, Norihisa Hoshino, Hiroyuki Noji, Tomoyuki Akutagawa, Kazuaki Ichimura and Kazushi Kinbara

Nature Commun. 2020, 11, 2924 (10.1038/s41467-020-16770-z) ("Behind the Paper" blog in Nature Research Bioengineering Community).

(51)

Reversible Formation of Multiple Stimuli-responsive Polymeric Materials through Processing Control of Trifunctional Amphiphilic Molecule

Takahiro Muraoka, Hidetaka Honda, Kota Nabeya and Kazushi Kinbara

Chem. Commun. 2020, 56, 7881–7884 (10.1039/D0CC02716B).

(50)

Sequence-dependent Bioactivity and Self-assembling Properties of RGD-containing Amphiphilic Peptides as Extracellular Scaffolds

Atsuya Ishida, Mio Oshikawa, Itsuki Ajioka and Takahiro Muraoka

ACS Appl. Bio Mater. 2020, 3, 3605–3611 (10.1021/acsabm.0c00240).

(49)

Biofunctional Molecules Inspired by Protein Mimicry and Manipulation

Takahiro Muraoka

Bull. Chem. Soc. Jpn. 2020, 93, 138–153 (10.1246/bcsj.20190315).

(48)

Abiotic Factors Promote Cell Penetrating Peptide Permeability in Enterobacteriaceae Models

Daichi Toyohara, Yasuhito Yokoi, Go Inoue, Takahiro Muraoka, and Tetsushi Mori

Front. Microbiol. 2019, 10, 2534 (10.3389/fmicb.2019.02534).

(47)

Glycine Substitution Effects on the Supramolecular Morphology and Rigidity of Cell-Adhesive Amphiphilic Peptides

Atsuya Ishida, Go Watanabe, Mio Oshikawa, Itsuki Ajioka, and Takahiro Muraoka

Chem. Eur. J. 2019, 25, 13523–13530 (10.1002/chem.201902083).

(46)

Formation of Giant and Small Cyclic Complexes from a Flexible Tripeptide Ligand Controlled by Metal Coordination and Hydrogen Bonds

Ryosuke Miyake, Akira Ando, Manami Ueno, and Takahiro Muraoka

J. Am. Chem. Soc. 2019, 141, 8675–8679 (10.1021/jacs.9b01541).

(45)

Coupling Effects of Thiol and Urea-Type Groups for Promotion of Oxidative Protein Folding

Shunsuke Okada, Motonori Matsusaki, Kenta Arai, Yuji Hidaka, Kenji Inaba, Masaki Okumura, and Takahiro Muraoka

Chem. Commun. 2019, 55, 759–762 (Highlighted in Inside Back Cover, 科学新聞2019年元日号2面, 現代化学, 10.1039/C8CC08657E).

(44)

Heat-Triggered Crystallization of Liquid Crystalline Macrocycles Allowing for Conductance Switching through Hysteretic Thermal Phase Transitions

Takahiro Muraoka, Tatsuya Shima, Takashi Kajitani, Norihisa Hoshino, Estelle Morvan, Axelle Grélard, Erick J. Dufourc, Takanori Fukushima, Tomoyuki Akutagawa, Kota Nabeya, and Kazushi Kinbara

Chem. Asian J. 2019, 14, 141–148 (Highlighted in Front Cover, 10.1002/asia.201801372).

(43)

Design of C2-Symmetric Alkaloidal Chiral Amphiphiles and Configurational Effects on Self-Assembly
Nana Tsuchiya, Yunosuke Ryu, Takahiro Muraoka, and Hiroki Oguri

Org. Biomol. Chem. 2018, 16, 9305–9313 (Highlighted in Front Cover, 10.1039/C8OB02287A).

(42)

Localization of Transmembrane Multiblock Amphiphilic Molecules in Phase-Separated Vesicles

Kazushi Kinbara, Kaori Umetsu, Hiroki Sonobe, Takahiro Muraoka, Naofumi Shimokawa and Masahiro Takagi

Faraday Discuss. 2018, 209, 315–328 (10.1039/C8FD00022K).

(41)

Thermal and Optical Properties of Multiblock Macrocycles with Hysteretic Polymorphic Transition

Kota Nabeya, Takahiro Muraoka, Norihisa Hoshino, Miho Aizawa, Takashi Kajitani, Tomoyuki Akutagawa, Atsushi Shishido, Takanori Fukushima, and Kazushi Kinbara

Mater. Chem. Front. 2018, 2, 969–974 (10.1039/C7QM00621G).

(40)

Enzymatically Cleavable Traceless Biotin Tag for Protein PEGylation and Purification

Adam Marcin Wawro, Yusuke Aoki, Takahiro Muraoka, Kouhei Tsumoto, and Kazushi Kinbara

Chem. Commun. 2018, 54, 1913–1916 (10.1039/C7CC05814D).

(39)

Multifarious Polymorphism of Multi-Block Amphiphilic Macrocycle Bearing Thermally Responsive Polyether Segment

Takahiro Muraoka, Tatsuya Shima, and Kazushi Kinbara

ACS Omega 2018, 3, 414–418 (10.1021/acsomega.7b01737).

(38)

Bio-inspired Multiblock Molecules for Membrane Functionalization

Takahiro Muraoka

Biol. Pharm. Bull. 2018, 41, 294–302 (10.1248/bpb.b17-00652, Invited Review, Current Topics).

(37)

Mechano-Sensitive Synthetic Ion Channels

Takahiro Muraoka, Kaori Umetsu, Kazuhito V. Tabata, Tsutomu Hamada, Hiroyuki Noji, Takashi Yamashita, and Kazushi Kinbara

J. Am. Chem. Soc. 2017, 139, 18016–18023 (10.1021/jacs.7b09515, Highlighted in JACS Spotlights).

(36)

Thermally-Induced Lateral Assembly of PEG-Containing Amphiphile Triggering Vesicle Budding

Rui Li, Takahiro Muraoka, and Kazushi Kinbara

Chem. Commun. 2017, 53, 11662–11665 (10.1039/C7CC06489F).

(35)

Newly Characterized Interaction Stabilizes DNA Structure: Oligoethylene Glycols Stabilize G-Quadruplexes CH–π Interactions

Hisae Tateishi-Karimata, Tatsuya Ohyama, Takahiro Muraoka, Peter Podbevsek, Adam M. Wawro, Shigenori Tanaka, Shu-ichi Nakano, Kazushi Kinbara, Janez Plavec, and Naoki Sugimoto

Nucleic Acids Res. 2017, 45, 7021–7030 (Highlighted in Front Cover, 10.1093/nar/gkx299).

(34)

Multigram Chromatography-Free Synthesis of Octa(ethylene glycol) p-Toluenesulfonate

Adam M. Wawro, Takahiro Muraoka, Maho Kato, and Kazushi Kinbara

Org. Chem. Front. 2016, 3, 1524–1534 (10.1039/C6QO00398B).

(33)

G-Quadruplexes with Tetraethylene Glycol-Modified Deoxythymidines Are Resistant to Nucleases and Inhibit HIV-1 Reverse Transcriptase

Hisae Tateishi-Karimata, Takahiro Muraoka, Kazushi Kinbara, and Naoki Sugimoto

ChemBioChem 2016, 17, 1399–1402 (selected as the Cover, 10.1002/cbic.201600162).

(32)

Contrasting Topological Effect of PEG-Containing Amphiphiles to Natural Lipids on Stability of Vesicles

Rui Li, Takahiro Muraoka, and Kazushi Kinbara

Langmuir 2016, 32, 4546–4553 (10.1021/acs.langmuir.6b00713).

(31)

Chromatography-Free Synthesis of Monodisperse Oligo(ethylene glycol) Mono-p-Toluenesulfonates and Quantitative Analysis of Oligomer Purity

Adam M. Wawro, Takahiro Muraoka, and Kazushi Kinbara

Polym. Chem. 2016, 7, 2389–2394.

(30)

Synthesis and Thermal Responses of Polygonal Poly(ethylene glycol) Analogues

Shunichi Kawasaki, Takahiro Muraoka, Tsutomu Hamada, Kazuki Shigyou, Fumi Nagatsugi and Kazushi Kinbara

Chem. Asian J. 2016, 11, 1028–1035 (selected as a Very Important Paper (VIP) & Top Cover, Highlighted in ChemistryViews, 10.1002/asia.201501381).

(29)

Bioinspired Multi-Block Molecules

Takahiro Muraoka and Kazushi Kinbara

Chem. Commun. 2016, 52, 2667–2678 (Feature Article, Selected as the Inside Back Cover, 10.1039/C5CC08052E).

(28)

Development of Stimuli-Responsive Multi-Block Amphiphiles

Takahiro Muraoka, Shunichi Kawasaki, and Kazushi Kinbara

J. Photopolym. Sci. Tec. 2015, 28, 579–582.

(27)

Protein Stabilization by an Amphiphilic Short Monodisperse Oligo(ethylene glycol)

Nabanita Sadhukhan, Takahiro Muraoka, Mihoko Ui, Satoru Nagatoishi, Kouhei Tsumoto, and Kazushi Kinbara

Chem. Commun. 2015, 51, 8457–8460.

(26)

Reversible Ion Transportation Switch by a Ligand-Gated Synthetic Supramolecular Ion Channel

Takahiro Muraoka, Takahiro Endo, Kazuhito V. Tabata, Hiroyuki Noji, Satoru Nagatoishi, Kouhei Tsumoto, Rui Li and Kazushi Kinbara

J. Am. Chem. Soc. 2014, 136, 15584–15595.

(25)

Grafting Synthetic Transmembrane Units to the Engineered Low-Toxicity alpha-Hemolysin to Restore Its Hemolytic Activity

Mihoko Ui, Kousuke Harima, Toshiaki Takei, Kouhei Tsumoto, Kazuhito V. Tabata, Hiroyuki Noji, Sumire Endo, Kimio Akiyama, Takahiro Muraoka, and Kazushi Kinbara

Mol. BioSyst. 2014, 10, 3199–3206.

(24)

Light-Triggered Vesicle Formation: Important Factors for Generation of Vesicles and Possible Applications

Tatsuya Shima, Takahiro Muraoka, Kazuhito V. Tabata, Hiroyuki Noji and Kazushi Kinbara

Pure Appl. Chem. 2014, 86, 1259–1267.

(23)

Single-Cell E. coli Response to an Instantaneously Applied Chemotactic Signal

Takashi Sagawa, Yu Kikuchi, Yuichi Inoue, Hiroto Takahashi, Takahiro Muraoka, Kazushi Kinbara, Akihiko Ishijima and Hajime Fukuoka

Biophys. J. 2014, 107, 730–739.

(22)

Thermodriven Micrometer-Scale Aqueous-Phase Separation of Amphiphilic Oligoethylene Glycol Analogues

Shunichi Kawasaki, Takahiro Muraoka, Haruki Obara, Takerou Ishii, Tsutomu Hamada and Kazushi Kinbara

Chem. Asian J. 2014, 9, 2778–2788 (Selected as the Back Cover).

(21)

Development of Self-Assembling Alternating Amphiphilic Compounds

Takahiro Muraoka, Nabanita Sadhukhan, Rui Li and Kazushi Kinbara

J. Photopolym. Sci. Tec. 2014, 27, 557–560.

(20)

Micrometer-Size Vesicle Formation Triggered by UV Light

Tatsuya Shima, Takahiro Muraoka, Tsutomu Hamada, Masamune Morita, Masahiro Takagi, Hajime Fukuoka, Yuichi Inoue, Takashi Sagawa, Akihiko Ishijima, Yuki Omata, Takashi Yamashita and Kazushi Kinbara

Langmuir 2014, 30, 7289–7295.

(19)

Thermally Driven Polymorphic Transition Prompting a Naked-Eye-Detectable Bending and Straightening Motion of Single Crystals

Tatsuya Shima, Takahiro Muraoka, Norihisa Hoshino, Tomoyuki Akutagawa, Yuka Kobayashi and Kazushi Kinbara

Angew. Chem. Int. Ed. 2014, 53, 7173–7178.

(18)

Thermoresponsive Self-assembly and Conformational Changes of Amphiphilic Monodisperse Short Poly(ethylene glycol)s in Water

Nabanita Sadhukhan, Takahiro Muraoka, Daisuke Abe, Yuji Sasanuma, Dwiky Rendra Graha Subekti and Kazushi Kinbara

Chem. Lett. 2014, 43, 1055–1057.

(17)

Transetherification on Polyols by Intra- and Intermolecular Nucleophilic Substitutions

Takahiro Muraoka, Kota Adachi, Rainy Chowdhury and Kazushi Kinbara

PLoS ONE 2014, 9, e91912.

(16)

Thermal-Aggregation Suppression of Proteins by a Structured PEG Analogue: Importance of Denaturation Temperature for Effective Aggregation Suppression

Takahiro Muraoka, Nabanita Sadhukhan, Mihoko Ui, Shunichi Kawasaki, Enrikko Hazemi, Kota Adachi, and Kazushi Kinbara

Biochem. Eng. J. 2014, 86C, 41–48.

(15)

Development and Functionalization of Structural Mimics of Multipass Transmembrane Proteins

Takahiro Muraoka and Kazushi Kinbara

J. Syn. Org. Chem. Jpn. 2013, 71, 1045–1050.

(14)

A Structured Monodisperse PEG for the Effective Suppression of Protein Aggregation

Takahiro Muraoka, Kota Adachi, Mihoko Ui, Shunichi Kawasaki, Nabanita Sadhukhan, Haruki Obara, Hidehito Tochio, Masahiro Shirakawa, and Kazushi Kinbara

Angew. Chem. Int. Ed. 2013, 52, 2430–2434 [Selected as a “Very Important Paper (VIP)” & a “Back Cover”, Highlighted in Wiley-JAPAN Science Cafe].

(13)

Ion Permeation by a Folded Multiblock Amphiphilic Oligomer Achieved by Hierarchical Construction of Self-Assembled Nanopores

Takahiro Muraoka, Tatsuya Shima, Tsutomu Hamada, Masamune Morita, Masahiro Takagi, Kazuhito V. Tabata, Hiroyuki Noji, and Kazushi Kinbara

J. Am. Chem. Soc. 2012, 134, 19788–19794. (DOI: 10.1021/ja308342g).

(12)

Development of Photoresponsive Supramolecular Machines Inspired by Biological Molecular Systems

Takahiro Muraoka and Kazushi Kinbara

J. Photoch. Photobio. C 2012, 13, 136–147.

(11)

Mimicking Multipass Transmembrane Proteins: Synthesis, Assembly and Folding of Alternating Amphiphilic Multiblock Molecules in Liposomal Membranes

Takahiro Muraoka, Tatsuya Shima, Tsutomu Hamada, Masamune Morita, Masahiro Takagi, and Kazushi Kinbara